Our findings provided a theoretical support for using CIF in FSLI intervention.Ĭertain foods, such as chili, litchi, pepper, etc., are known as “heating” foods in traditional Chinese medicine. In summary, CIF inhibits FSLI by modulating the gut microbiota, increasing SCFAs levels and inhibiting excessive LPS translocation into the blood. In addition, CIF increased the α diversity and number of OTUs in the gut microbiota, restored the abundance of Lactobacillus and increased the total content of SCFAs in the feces. After a high dose of CIF intervention, serum levels of TNF-α and LPS were reduced by 62.8% and 77.44%. Capsaicin was found to increase serum TNF-α levels, demonstrating a successful model induction. day −1) were tested as the intervention. In this study, we administered capsaicin to mice by gavage to establish a FSLI model. This study showed that CIF can reduce FSLI and represents a new strategy to intervene in chronic inflammatory diseases. However, its effects and mechanisms in reducing food-induced systemic low-grade inflammation (FSLI) remain unclear. flower (CIF) is a common herb with a strong anti-inflammatory effect in drug-induced models, based on the theory of “medicine and food homology”. Systemic low-grade inflammation induced by unhealthy diet has become a common health concern as it contributes to immune imbalance and induces chronic diseases, yet effective preventions and interventions are currently unavailable.
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